The close relations that the Spanish university system maintains with the university systems of Latin America and the Caribbean, and Spain's international commitment to the construction of the Ibero-American Knowledge Space, invite ANECA since its creation to use its efforts for the promotion and assurance of quality in the region in alliance with organisations and institutions of reference.

The Agency actively participates in the Ibero-American System for Quality Assurance in Higher Education (SIACES) through one of its memberships. This system is organically linked to the Ibero-American General Secretariat (SEGIB) and is constituted as a network of cooperation between national agencies that promotes, among other issues, the harmonisation of criteria and procedures, the recognition of good practices and mutual trust for the recognition of degrees and periods of study.

ANECA's involvement is carried out through its participation in different forums, and its role in cooperation, support and collaboration projects and initiatives related, among other issues, to the improvement of standards and good practices for quality enhancement, the training of quality teams in the Latin American and Caribbean region and actions aimed at mutual recognition.